abstract：:Right ventricular (RV) afterload consists of both resistive and capacitive (pulsatile) components. Total afterload can be measured directly with pulmonary artery input impedance spectra or estimated, either with lumped-parameter modeling or by pressure-volume analysis. However, the inverse, hyperbolic relationship bet...

journal_title：Pulmonary circulation

authors： Tedford RJ

更新日期：2014-06-01 00:00:00

abstract：:Insulin resistance is highly prevalent in pulmonary arterial hypertension (PAH) patients. However, the long-term impact of diabetes mellitus (DM) on survival in PAH is unclear. Insulin resistance and DM are associated with left ventricular steatosis and dysfunction, but whether the right ventricle (RV) might be affect...

journal_title：Pulmonary circulation

authors： Benson L,Brittain EL,Pugh ME,Austin ED,Fox K,Wheeler L,Robbins IM,Hemnes AR

更新日期：2014-06-01 00:00:00

abstract：:There are limited data on the management of pulmonary arterial hypertension (PAH) in the elderly; therefore, this analysis compared the safety and efficacy of tadalafil between patients ≥65 and <65 years old. This was a post hoc analysis of the randomized, double-blind, placebo-controlled phase 3 Pulmonary Arterial Hy...

journal_title：Pulmonary circulation

authors： Berman-Rosenzweig E,Arneson C,Klinger JR

更新日期：2014-03-01 00:00:00

abstract：:Pulmonary endarterectomy (PEA) is the standard therapy for chronic thromboembolic pulmonary hypertension (CTEPH). Balloon pulmonary angioplasty (BPA) is an alternative therapy for such patients. Here we report the case of a 60-year-old woman who presented with severe CTEPH resulting in low cardiac output and liver fai...

journal_title：Pulmonary circulation

authors： Tsuji A,Ogo T,Demachi J,Ono Y,Sanda Y,Morita Y,Fukuda T,Nakanishi N

更新日期：2014-03-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a major complication of sickle cell disease (SCD). Low levels of apolipoprotein A1 (Apo-A1) have been implicated in the development of PAH in SCD. We speculate that lower levels of Apo-A1 are related to dysregulation of the ubiquitin-proteasome pathway (UPP). Of 36 recruited pa...

journal_title：Pulmonary circulation

authors： Anjum F,Lazar J,Soh J,Albitar M,Gowda S,Hussain MM,Wadgaonkar R

更新日期：2013-12-01 00:00:00

abstract：:Pulmonary hypertension is recognized as a leading cause of morbidity and mortality in patients with sickle cell disease (SCD). We now report benchtop phenotyping from the explanted lungs of the first successful lung transplant in SCD. Pulmonary artery smooth muscle cells (PASMCs) cultured from the explanted lungs were...

journal_title：Pulmonary circulation

authors： Rogers NM,Yao M,Sembrat J,George MP,Knupp H,Ross M,Sharifi-Sanjani M,Milosevic J,St Croix C,Rajkumar R,Frid MG,Hunter KS,Mazzaro L,Novelli EM,Stenmark KR,Gladwin MT,Ahmad F,Champion HC,Isenberg JS

更新日期：2013-12-01 00:00:00

abstract：:Abstract Changes in voltage-gated K(+) (Kv) channel function contribute to the pathogenesis of pulmonary hypertension. Yet the mechanisms underlying Kv channel impairments in the pulmonary circulation remain unclear. We tested the hypothesis that reactive oxygen species (ROSs) contribute to the Kv channel dysfunction ...

journal_title：Pulmonary circulation

authors： Fike CD,Aschner JL,Kaplowitz MR,Zhang Y,Madden JA

更新日期：2013-09-01 00:00:00

abstract：:Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening condition characterized by single or recurrent pulmonary thromboemboli, which promote pulmonary vascular remodeling. MicroRNA (miRNA), is a small, noncoding RNA that is involved in multiple cell processes and functions and may partici...

journal_title：Pulmonary circulation

authors： Wang L,Guo LJ,Liu J,Wang W,Yuan JX,Zhao L,Wang J,Wang C

更新日期：2013-09-01 00:00:00

abstract：:Most subtypes of pulmonary arterial hypertension (PAH) are characterized by a greater susceptibility to disease among females, although females with PAH appear to live longer after diagnosis. While this "estrogen paradoxȍ of enhanced female survival despite increased female susceptibility remains a mystery, recent pro...

journal_title：Pulmonary circulation

authors： Austin ED,Lahm T,West J,Tofovic SP,Johansen AK,Maclean MR,Alzoubi A,Oka M

更新日期：2013-04-01 00:00:00

abstract：:PH occurs alone or in association with many disorders. Many patients with transthoracic echocardiography (TTE) findings suggesting PH never receive additional evaluation. Patient characteristics and echocardiographic data associated with increased recognition of PH have not been fully evaluated. We evaluated TTE repor...

journal_title：Pulmonary circulation

authors： Kingrey JF,Panos RJ,Ying J,Meganathan K,Vandivier R,Elwing JM

更新日期：2013-04-01 00:00:00

abstract：:Microparticle release by vascular endothelium has been implicated in various cardiovascular pathologies. Ventilator-induced lung injury (VILI) is a life-threatening complication of mechanical ventilation at high tidal volumes associated with excessive mechanical stretch of pulmonary vascular endothelial cells. However...

journal_title：Pulmonary circulation

authors： Vion AC,Birukova AA,Boulanger CM,Birukov KG

更新日期：2013-01-01 00:00:00

abstract：:In pulmonary hypertension, as in many other diseases, there is a need for a smarter approach to evaluating new treatments. The traditional randomized controlled trial has served medical science well, but constrains the development of treatments for rare diseases. A workshop was established to consider alternative clin...

journal_title：Pulmonary circulation

authors： Grieve AP,Chow SC,Curram J,Dawe S,Harnisch LO,Henig NR,Hung HM,Ivy DD,Kawut SM,Rahbar MH,Xiao S,Wilkins MR

更新日期：2013-01-01 00:00:00

abstract：:Transforming growth factor-β (TGF-β) inhibition is an investigational therapy for pulmonary arterial hypertension with promising results in experimental studies. The present work compared this approach with endothelin-receptor blockade and evaluated the effects of combined administration. Pulmonary arterial hypertensi...

journal_title：Pulmonary circulation

authors： Megalou AJ,Glava C,Vilaeti AD,Oikonomidis DL,Baltogiannis GG,Papalois A,Vlahos AP,Kolettis TM

更新日期：2012-10-01 00:00:00

abstract：:Right ventricular (RV) function is a strong independent predictor of outcome in a number of distinct cardiopulmonary diseases. The RV has a remarkable ability to sustain damage and recover function which may be related to unique anatomic, physiologic, and genetic factors that differentiate it from the left ventricle. ...

journal_title：Pulmonary circulation

authors： Brittain EL,Hemnes AR,Keebler M,Lawson M,Byrd BF 3rd,Disalvo T

更新日期：2012-07-01 00:00:00

abstract：:The development of pulmonary arterial hypertension (PAH) in pediatric patients has been linked to the production of the arachidonic acid metabolite, thromboxane A(2) (TxA(2)). The present study evaluated the therapeutic effect of furegrelate sodium, a thromboxane synthase inhibitor, on the development of PAH in a neon...

journal_title：Pulmonary circulation

authors： Hirenallur-S DK,Detweiler ND,Haworth ST,Leming JT,Gordon JB,Rusch NJ

更新日期：2012-04-01 00:00:00

abstract：:Endothelial dysfunction plays an important role in the pathogenesis of pulmonary arterial hypertension (PAH) in sickle cell disease (SCD). A variety of evidence suggests that circulating endothelial progenitor cells (EPCs) play an integral role in vascular repair. We hypothesized that SCD patients with PAH are deficie...

journal_title：Pulmonary circulation

authors： Anjum F,Lazar J,Zein J,Jamaleddine G,Demetis S,Wadgaonkar R

更新日期：2012-01-01 00:00:00

abstract：:Schistosomiasis-associated pulmonary arterial hypertension (PAH) is one of the most common causes of pulmonary hypertension worldwide. A potential contributing mechanism to the pathogenesis of this disease is a localized immune reaction to retained and persistent parasite-derived antigens. We sought to identify Schist...

journal_title：Pulmonary circulation

authors： Graham BB,Chabon J,Bandeira A,Espinheira L,Butrous G,Tuder RM

更新日期：2011-10-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a rapidly progressive and fatal disease for which there is an ever-expanding body of genetic and related pathophysiological information on disease pathogenesis. The most common single culprit gene known is BMPR2, and animal models of the disease in several forms exist. There is...

journal_title：Pulmonary circulation

authors： Fessel JP,Loyd JE,Austin ED

更新日期：2011-07-01 00:00:00

abstract：:This study aimed to identify receptors mediating sphingosine-1-phosphate (S1P)-induced vasoconstriction in the normotensive and chronic hypoxia-induced hypertensive rat pulmonary circulation. In isolated perfused lungs from normoxic rats, infusion of S1P caused a sustained vasoconstriction, which was not reduced by co...

journal_title：Pulmonary circulation

authors： Ota H,Beutz MA,Ito M,Abe K,Oka M,McMurtry IF

更新日期：2011-07-01 00:00:00

abstract：:N-terminal pro B-type natriuretic peptide (NT-proBNP) is a product of cleavage of the cardiac prohormone pro B-type natriuretic peptide into its active form. It has proven to be a useful biomarker in left heart failure. However, studies examining the utility of serial measurements of NT-proBNP in pulmonary arterial hy...

journal_title：Pulmonary circulation

authors： Soon E,Doughty NJ,Treacy CM,Ross RM,Toshner M,Upton PD,Sheares K,Morrell NW,Pepke-Zaba J

更新日期：2011-04-01 00:00:00